![]() You can shoot up to 220gr as subs as long as you run the round nose bullets. Unless you intend on only shooting specialty machined copper expanding petal type subsonic projectiles and believe the marketing around the rotational energy of such bullet killing game any better than a subsonic soft lead cast HP or a tumbling after impact long 240gr SMK then dont bother with anything over 1-8" twist.Ī 1-12" to 1-10" will actually shoot a wider range of subs and high velocitie bullets better than the 1-8" and 1-7". The slower twist also combats bore leading. They are a short bullet with a blunt nose and base so dont require a fast twist barrel to stabilize them. The best twist for that cast 151gr HP at subsonic speeds is a 1-12" to 1-13". Lighter bullets in a fast twist don't nessisarally shoot slower than a slower twist will but do reach pressure faster which can in turn effect final achievable velocity. ![]() If you are using cast lead in a 1-7" you will also get a lot of bore leading which also destroys accuracy. 308 with the all the longest and heaviest bullets available such as the 240gr SMK. 308 were designed for use with the heaviest and longest jacketed bullets to run at subsonic speeds.ġ-8" gives the best subsonic accuracy in. I totally agree with Friwi, all the best accuracy I have achieved with both subsonics and high velocity was a twist rate of "just enough" and faster twists barrels groups have always opened up.įast twist barrels in. The team down in the butts nic named it the bumblebee as the bullets whizzed over with a deep buzz at sub speeds rather than the sharp crack they were used to. Low Flash, Low Noise & Accuracy are what I Need. Most Shots will be 50yds or Less on Deer/Man Size Targets & Target May or May Not be Armed. 308WIN/7.62X51NATO Could Definitely Use a Load that Shoots at 1000fps w/ 165-200gr Bullets. They were still perfectly stable and grouping well with round holes at 1000y. Anyone Have Load Data for SubSonic Loads for the. 338 Whispers ran 1-9" twist Shilen and trueflite barrels shooting 300gr SMKs and 300gr Berger hybrids at 1040fps MV. Ask Wingman what was the twist rate of his 338br and what projectiles he was shooting subsonic and how they where flying.My.
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![]() The term checkmate is, according to the Barnhart Etymological Dictionary, an alteration of the Persian phrase "shāh māt" ( شاه مات) which means "the King is helpless". All rights reserved.Look up checkmate in Wiktionary, the free dictionary. Nivolumab plus ipilimumab provided significant and clinically meaningful improvements in overall survival versus standard-of-care chemotherapy, supporting the use of this first-in-class regimen that has been approved in the USA as of October, 2020, for previously untreated unresectable MPM.Ĭopyright © 2021 Elsevier Ltd. Three (1%) treatment-related deaths occurred in the nivolumab plus ipilimumab group (pneumonitis, encephalitis, and heart failure) and one (<1%) in the chemotherapy group (myelosuppression). Grade 3-4 treatment-related adverse events were reported in 91 (30%) of 300 patients treated with nivolumab plus ipilimumab and 91 (32%) of 284 treated with chemotherapy. 2-year overall survival rates were 41% (95% CI 35♱-46♵) in the nivolumab plus ipilimumab group and 27% (21♹-32♴) in the chemotherapy group. At the prespecified interim analysis (database lock Apmedian follow-up of 29♷ months ), nivolumab plus ipilimumab significantly extended overall survival versus chemotherapy (median overall survival 18♱ months vs 14♱ months hazard ratio 0♷4 p=0♰020). 467 (77%) of 605 participants were male and median age was 69 years (IQR 64-75). ![]() This study is registered with, NCT02899299, and is closed to accrual.īetween Nov 29, 2016, and April 28, 2018, 713 patients were enrolled, of whom 605 were randomly assigned to either nivolumab plus ipilimumab (n=303) or chemotherapy (n=302). The primary endpoint was overall survival among all participants randomly assigned to treatment, and safety was assessed in all participants who received at least one dose of study treatment. ![]() Eligible participants were randomly assigned (1:1) to nivolumab (3 mg/kg intravenously once every 2 weeks) plus ipilimumab (1 mg/kg intravenously once every 6 weeks) for up to 2 years, or platinum plus pemetrexed chemotherapy (pemetrexed plus cisplatin or carboplatin ) once every 3 weeks for up to six cycles. Eligible individuals were aged 18 years and older, with previously untreated, histologically confirmed unresectable MPM, and an Eastern Cooperative Oncology Group performance status of 0 or 1. This open-label, randomised, phase 3 study (CheckMate 743) was run at 103 hospitals across 21 countries. We hypothesised that this regimen would improve overall survival in MPM. Nivolumab plus ipilimumab has shown clinical benefit in other tumour types, including first-line non-small-cell lung cancer. 19 Bichat-Claude Bernard University Hospital, AP-HP, Université de Paris, Paris, France.Īpproved systemic treatments for malignant pleural mesothelioma (MPM) have been limited to chemotherapy regimens that have moderate survival benefit with poor outcomes.18 Bristol Myers Squibb, Princeton, NJ, USA.17 Centro Oncológico, Médica Sur-Instituto Nacional de Enfermedades Respiratorias, Mexico City, Mexico.16 Department of Lung Cancer and Chest Tumours, Maria Sklodowska-Curie National Research Institute of Oncology, Warsaw, Poland.15 Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.14 Aix Marseille University, APHM, INSERM, CNRS, CRCM, Hôpital Nord, Multidisciplinary Oncology and Therapeutic Innovations Department, Marseille, France.13 Erasmus MC Cancer Institute, Rotterdam, Netherlands.12 Centro Médico Nacional Siglo XXI, Mexico City, Mexico.11 Hôpital Côte de Nacre CHU de Caen, Caen, France.10 H Lee Moffitt Cancer Center & Research Institute, Tampa, FL, USA.9 UCSF Helen Diller Family Comprehensive Cancer Center, San Francisco, CA, USA.8 Royal Marsden Hospital, London, UK Institute of Cancer Research, London, UK.6 MD Anderson Cancer Center, Houston, TX, USA.5 Lausanne University Hospital, Lausanne, Switzerland.4 Okayama Rosai Hospital, Okayama, Japan.3 Medical School, University of Western Australia Perth, WA, Australia Department of Medical Oncology, Sir Charles Gairdner Hospital, Perth, WA, Australia.Electronic address: 2 Pulmonary and Thoracic Oncology, University of Lille, CHU Lille, INSERM U1189, OncoThAI, Lille, France. 1 The Netherlands Cancer Institute and Leiden University Medical Center, Amsterdam, Netherlands. |
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